February 25, 2024

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worldwide online news

Year: 2023

Embrace the Season With LEVEL8 Luggage’s Festive Collection
2 min read
Embrace the Season With LEVEL8 Luggage’s Festive Collection

Curate Memorable Journeys with Travel Companions Tailored for Christmas 2023

Amidst the approaching holiday season, a time synonymous with warmth and joy, LEVEL8 Luggage extends an invitation to transform your travels into more than just a journey – into cherished adventures.

The CEO, Steven Lin, eagerly shares news of a special holiday gathering, offering thoughtful companions for the upcoming Christmas of 2023.

Featured in this festive assembly are the Luminous Textured Carry-On 20" and the graceful Voyageur Check-in 28". These pieces, not merely luggage but storytellers in their own right, carry with them tales of exploration and discovery. The Voyageur collection, celebrated for its wide-handle design, enduring German-made Makrolon® polycarbonate hard shell and quiet 360° spinner wheels, is more than a companion; it's an enriching part of your travel narrative.

Rooted in the vibrant streets of New York City, LEVEL8 has been a pioneer in curating travel solutions for the modern, always-on-the-go individual. We take pride in offering luggage and travel accessories that seamlessly blend durability and reliability with a touch of style and elegance.

"Travel should be a joyous adventure, not a burden. Our products are crafted with the needs and lifestyle of contemporary travelers in mind," shares Steven Lin. "The positive response from our customers consistently reinforces our confidence in the quality of our range," he adds.

This holiday season, rather than a sale, LEVEL8 extends an invitation to enrich your journeys with warmth and comfort. Enjoy the embrace of complimentary shipping in the U.S., Canada, U.K., and EU, making this the perfect moment to embark on a voyage with LEVEL8. Join us in adding a touch of joy to your travels, where each adventure feels like coming home. After all, it's not just luggage; it's a chapter in your own extraordinary story.

Contact Information:

Chanky Chang

Marketing Manager

[email protected]

Original Source:

Embrace the Season With LEVEL8 Luggage's Festive Collection

The post Embrace the Season With LEVEL8 Luggage’s Festive Collection first appeared on RSVTV news.

Statement from President Joe Biden on FDA Approval of Gene Therapies to Treat Sickle Cell Disease
1 min read
Statement from President Joe Biden on FDA Approval of Gene Therapies to Treat Sickle Cell Disease

As we’ve seen throughout our history, when the U.S. government invests in innovation, we can achieve breakthroughs that would otherwise be impossible, and save and improve lives on a vast scale. Today, FDA announced a major breakthrough for the 100,000 Americans who live with sickle cell disease. Living with sickle cell often has meant putting […]

The post Statement from President Joe Biden on FDA Approval of Gene Therapies to Treat Sickle Cell Disease first appeared on Social Gov.

Biden-Harris Administration Announces $1.5 Billion Available through the 2024 RAISE Grant Program  
3 min read
Biden-Harris Administration Announces .5 Billion Available through the 2024 RAISE Grant Program  

As in previous years, popular RAISE Discretionary Grant Program will support transportation projects with significant local or regional impact. WASHINGTON — The U.S. Department of Transportation has published a Notice of Funding Opportunity (NOFO) for $1.5 billion in grant funding through the Rebuilding American Infrastructure with Sustainability and Equity (RAISE) discretionary grant program for 2024. […]

The post Biden-Harris Administration Announces $1.5 Billion Available through the 2024 RAISE Grant Program   first appeared on Reliable News.

Readout of White House Event on Inclusive Approaches to Education in Artificial Intelligence and Computer Science
3 min read
Statement from President Joe Biden on FDA Approval of Gene Therapies to Treat Sickle Cell Disease

On Tuesday, December 5, the Biden-Harris Administration hosted an event convening roughly 60 teachers, advocates, officials, and other education leaders to discuss inclusive approaches to artificial intelligence (AI) education in computer science. The event, held during Computer Science Education Week—an annual week of celebration organized by the Computer Science Teachers Association— acknowledged the work of […]

The post Readout of White House Event on Inclusive Approaches to Education in Artificial Intelligence and Computer Science first appeared on Social Gov.

Research for the Treatment of a ‘Black Sheep’ Cancer Moves to Human Clinical Trials
5 min read
Research for the Treatment of a ‘Black Sheep’ Cancer Moves to Human Clinical Trials

With $3.5 million in funding from the GI Research Foundation, a team at the MD Anderson Cancer Center explores a one-two punch to combat BRAF-mutated colorectal cancer and its “dismal prognosis.”

Many cancers caused by the mutation of the BRAF gene respond well to a class of immunotherapies known as BRAF-inhibitors. BRAF-mutated colorectal cancer, however, almost never does. Doctors have known this for years, but they are yet to find a treatment that works well for most patients.

“BRAF-inhibitors provide very different clinical outcomes,” said Dr. Scott Kopetz, a Professor and Associate Vice President for Translational Integration at The University of Texas MD Anderson Cancer Center. “They work amazingly well in melanoma, for example, but are less effective in colorectal cancer.”

“BRAF [in colorectal cancer] is that odd uncle who doesn’t behave like the rest of the family. The black sheep. Is he even related? The usual rules don’t apply.”

Dr. Kopetz and his team’s most recent studies of this black sheep are now moving from research in mice to clinical trials in humans. These trials were approved by the National Cancer Institute in October and will launch in early 2024. 

The GI Research Foundation helped support the work with mice models, along with several other aspects of the team’s BRAF-related research. The $3.5 million grant is part of the foundation’s massive CA CURE initiative.

“Last year, we were able to deliver more than $18 million to researchers across the country to improve diagnostics and develop immunotherapies and personalized vaccines in gastrointestinal cancers through CA CURE,” said Katie Chudnovsky, chair of the GI Research Foundation’s Board of Directors. “Patients need treatments like those being developed by Dr. Kopetz – so very urgently – and we are thrilled to see this team’s work moving to clinical trials so quickly.”

BRAF-mutated colorectal cancer comes with a “dismal prognosis,” according to research in the International Journal of Molecular Sciences, and the median patient survives less than a year.

This new form of treatment for BRAF-mutated colorectal cancer relies on what Kopetz called a “two-hit hypothesis.” That is, these cancers are caused by the combination of mutations in the BRAF gene and epigenetic dysregulation. Epigenetic dysregulation refers to the fact that behaviors and environment can impact how a person’s genes behave.

Here, researchers have found that a mutation to the BRAF gene changes the production of proteins that cause healthy cells to grow into cancerous tumors. Other forms of BRAF-mutated cancer respond well to BRAF-inhibitor immunotherapy that can halt the production of those proteins. 

In BRAF-mutated colorectal cancer, however, another piece of DNA is unable to express itself entirely. Those genes typically create natural tumor suppressors that fight early cancer growth. Carbon molecules called methyl groups attach themselves to the DNA and prevent the DNA from building cancer-suppressing proteins. That “methylation” is the epigenetic dysregulation in this case, likely caused by inflammation, diet, or external environmental factors.

If doctors can stop the proteins that cause cancer and stop the bromodomains, they might be able to produce a one-two punch to combat their double hit hypothesis. The treatment would slow BRAF-mutated colorectal cancer growth and encourage natural cancer suppressors.

That idea will be tested in the human trials that were recently approved by the National Cancer Institute. A BRAF-inhibitor, an EGFR-inhibitor, and a bromodomain-inhibitor will be administered to patients. This combined treatment was developed by Kopetz and his colleague Dr. Kunal Rai, an Associate Professor of Genomic Medicine at MD Anderson.

The research moved from the GI Research Foundation-funded mouse models to human trials exceptionally quickly, according to Kopetz.

“It’s rare for the pieces to come together like this,” he said. “Lots of times, this would be two years of work to get the human trials up and running. But we were able to show how clearly this approach worked in multiple mouse models and that really sped things up.”

Other funding from the GI Research Foundation will help speed things up even further. “The new technologies and techniques that Dr. Kopetz and his team are exploring will give them the ability to innovate that much faster. It provides the entire community with the means to gather high-quality data more quickly and get it into trials and ultimately into the clinic,” said Dr. David Rubin. Rubin is the Joseph B. Kirsner Professor of Medicine and Chief of the Section of Gastroenterology, Hepatology and Nutrition at University of Chicago Medicine. He is also GI Research Foundation’s Senior Scientific Advisor. 

“The GI Research Foundation has a legacy of funding high risk-high reward and innovative science, and doing so efficiently and extraordinarily effectively. Kopetz and his colleagues were recipients of a dedicated campaign that we launched in 2022 to tackle the most difficult challenges of colorectal cancer.”

“Support from the GI Research Foundation allows us to accelerate our work and try some out of the box stuff,” Kopetz said. “We have amazing animal models, but there’s no substitute for understanding cancer and treatments with the patients themselves. We want to develop the tools we need so we can learn as much as possible from them and help them as much and as quickly as we can.”

About the GI Research Foundation

The GI Research Foundation was founded in 1961 by grateful patients and friends of the late Dr. Joseph B. Kirsner, a pioneer in gastroenterology who devoted his life to medicine, teaching, and patient care. Today, the University of Chicago Medicine’s Digestive Diseases Center, which is supported by the foundation, is internationally recognized for research-driven medicine and its team of highly specialized physicians. For more information, see: https://giresearchfoundation.org/

About the University of Chicago Digestive Diseases Center

The Digestive Diseases Center at the University of Chicago Medicine is a collaborative, multidisciplinary network of physicians, researchers and affiliated health professionals who share a legacy of innovation and a common purpose: to improve the lives of patients who suffer from digestive diseases. For more information, see: https://www.uchicagomedicine.org/conditions-services/digestive-diseases

Contact Information:

Jackie Casey

Executive Director

[email protected]

312-332-1350

Original Source:

Research for the Treatment of a 'Black Sheep' Cancer Moves to Human Clinical Trials

The post Research for the Treatment of a ‘Black Sheep’ Cancer Moves to Human Clinical Trials first appeared on Social Gov.